I am most familiar with the Isuzu NPR class 4 and 5 trucks, 4cyl 4.8L and 5.2L Duramax ('03 newer) They were also available with SB chevy (R code 5.7L) gas engines and currently with LSx 6.0 gas engines using 4L80e trans ( early models had issues with busting the bell housings)
They get decent mileage for what they are, they ARE NOT power houses, you won't go anywhere fast when loaded. They ride like crap when not loaded.
buying one used, beware, they have been USED HARD and had minimum of maint. They are "supposed" to have a valve adjustment periodically, it rarely if ever happens, though if it does, they sound and run SO much better. ( stupid easy to do, but you can't convince the owners it's a needed service)
The ones I am most familiar with have the Zexel injection pump, unfortunatly I never got to play with 'em other than when doing a full on engine build (not cheap)
The 5.2L Dmax engines were/are common rail using a Bosch injection pump. VERY reliable.
The engines are a timing nightmare, the rear of the engine looks like the insides of a clock with all the gears running the injection pump and cam.
IF you happen to loose a boost hose, it's DOA, won't get out of it's own way on level ground, worse if loaded.
the Autos and manual trans behind the diesels are Aisin if I remember right.
wierd size tires, especially steer tires
Honestly, if you are looking for a vehilce hauler, go up a bit and get a 6-7 series Isuzu, 7.8L engine is damn near bullet proof, though still pretty repair intensive if there becomes an issue.
The 4.8/5.2/7.8 engines are related in design, but just different enough that you can't use parts cross platform.
All are dry sleeve engine blocks, so a rebuild is reasonably doable as long as block is good, head is iron and rebuildable
You CANNOT get the engines as a complete assy from the factory ( I'm sure there are rebuilders that do ) must be ordered piece by piece and ain't cheap ( the one I quoted was $15k with labor)