2 guys I know who are VERY anal about their setups (fer gawds sake, he uses 8 straps to tie down his FJ!) lost 3 tires on the way back from Tellico. The other guy lost 2. All Carlisle's. Now on Goodyears, and no more problems.
The RV guys don't think too highly of them either, since when THEY lose a tire, it can cause thousands in damage to the 5th wheel or TT.