From Winston DO NOT go any other way than 52/77/81! I have tried many different ways to get from Greensboro to Harlan and no way is as good as 77/81 IMO. 52N to I77N to I81S. Take exit 57A north on I26/Hwy23, stay on Hwy23 to Duffield, in Duffield at Hardees turn left at the light on 58/421, stay on 421 through Harlan, take a right on Hwy 38 at the Waffle House. From our area this route has the best roads and least grade. The pull up Fancy Gap on I77 and out of Duffield on 421N are the only major climbs. Takes me 5 hours from Greensboro with 1 gas stop and 1 rest stop.