I-26W is a nice straight pull that our crew likes . IMHO I don't think 26E is any worse than Black Mtn, we had 4rigs run up it at a steady 75mph last time. If heading to Harlan via 421 there is a MONSTER of a hill that way. 2lane and steep! You better have faith in your tow rig on that hill.
A not so harsh way to Harlan is 40/25E/119. Slightly longer but not so harsh on the rig.