Yes, setup is a breeze. Go outside, turn it on and press OK to the warning. Just wait a few minutes (yes, it's slow) and it will figure out where you are.
Adding your home address, saving favorites, and finding Points Of Interest is fairly easy. It's all touch, so not everything has a button. The map can be dragged, speed/distance/intersection details, and plenty of other cool things to distract you from driving!
You'll probably need to download and install map updates. If so, then that takes several hours. 2 GB file for Garmin and Navigon. (Note: the Nuvi 200 requires you to delete some files first. Do a google search if you buy that one.)