On my XR10, I run either Hot Bodies Sedonas or Losi Boss Claws (red compound), depending on the type of rock, amount of dust/dirt, etc. Have a set of each mounted and ready at all times.
On my Night Crawler I mainly only run the Sedonas but will run the Boss Claws every once in awhile. Don't have enough extra wheels for this truck, so have to unmount/remount tires if I want to change them.