I've been driving a 2WD '07 Trailblazer as my work vehicle for the last few years. Gets around 16 MPG, and that is loaded down with a ridiculous amount of crap, and a driver with a very heavy foot. Other than routine maintenance it has been relatively trouble free. I've had the drivers door lock mechanism break once, right now my rear hatch won't open, and that's about it in 98k miles or so of driving.
They aren't making the Trailblazer anymore, so as they age out of the fleet my company started buying Grand Cherokees to replace them with, and pretty much every tech who has one of the new Jeeps tells me that they wish they had their old Trailblazer back; it has more interior room, way more power, more comfortable seats, and a much nicer ride is pretty much their concensus. The cup holders do have a pretty piss poor design, but that is just nit picking I guess. It pains me to say it since I'm a Ford guy at heart, but the 2WD Trailblazer is a pretty decent vehicle for a daily driver as long as you don't need to ever take it off road. We service a lot of radio tower sites, many of which are out in muddy fields and up on mountain tops with very bad roads going up to them, and in stock form this truck is barely adequate for that task. It has just pathetic ground clearance, and God help you if you forget to turn off the traction control when you're in the mud. Not surprisingly the 4WD ones are way better at handling that stuff.