well, for the rear it'd be simple to cut and weld on new spring perches to align with your driveshaft. The front, for that amount of lift, it would be possible to simply weld on new perches with lockout hubs. But I have seen the u-joint bind on front axles when the right-front tire flexes full out. So if you don't want that to happen, its impossible to angle the pinion enough upward without harming the steering therefore needing to relocate the knuckles.
Anyone else can chime in if they can think of anything I'm missing on.