Yepp, I'm from STL...Go see a Cardinals game and then hit Laclede's landing downtown...then when that closes down @ 2am go to East St. Louis...Clubs open all nite long over there...
Or go wheelin' @ Hannibal Rocks (~1hr north of St. Louis or Flat Nasty ORV Park in Salem, Mo (Ozark mtns) ~ 3 hrs South of STL
Or you can tour the ex-Anheuser Busch Brewery now owned by InBev
With the Kids you can go to St. Louis Zoo downtown or Grants Farm, Fishin at Busch Wildlife Area, Science Center, Transportation Museum, etc.