I have a precision plasma 4x4 table with candcnc electronics and I run a hypertherm powermax 65 cutter. I think the best advice I can give you is to plan on spending as long as it takes to get it right. With a proprietary system like plasmacam you "should" have a lot less setup time than me. I have probably 40-50 hrs in getting mine dialed in to the point that it'll cut how I want.
Another big thing that I see people struggling with is what travel speed, pierce height, pierce delay, amperage, and cut height to run at for a given material. Hypertherm includes all these parameters in their manuals but many manufacturers don't. All of these variables really contribute to cut quality and consumable life so get it right before you go for the gusto.
Do you have auto torch height control? If not I strongly recommend you get it. If I'm not mistaken with plasma cam it's already in the software you just have to pay to unlock it. It is very nice to be able to cut thin stuff and not have weights all over the table holding it flat.
Cutting holes has been my biggest hurdle. Initially I was able to cut beautiful round bolt holes. No dross top or bottom but the bottom of the hole was slightly smaller than the top so a bolt wouldn't drop through. They all had to be reamed slightly. Most guys seem to cut slightly larger holes to compensate but I don't like the fact that only maybe 1/4 of the material thickness is tight on the bolt. Once that spot wears down the hole is too loose. After hours and hours of trial and error I now have mine to where I can cut a .375 hole in .25 plate that actually measures .375 and has no taper. Torch height, travel speed and most importantly lead in and lead out make the difference. I will not give away all my secrets since many people are apparently still not able to get clean holes
Tip ups do suck and cause you to have to really keep an eye on what's being cut but my software allows you to adjust your traverse height between cuts. I'd imagine yours will too. Keeping it high as it goes from cut to cut makes it a little easier to not sit and babysit it.
Most people I've seen who don't have good luck with getting quality cuts just don't take the time to dial their table in right. There are tons of online forums with guys who are very knowledgable and have some great write-ups on how to work out issues so read read read.
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