My two cents... for what their worth...
One good, heavy chain on rear, running under the axle (both sides) and up/over the diff, anchored to both sides of the trailer. Then, two good quality ratchet straps, one on each side of the front axle (not crossed). It's highly doubtful you can accelerate fast/hard enough to break them, and a vehicle tied down this way will not slide sideways easily. However, if some idiot pulls out in front of you, and you hit him, you don't want whatever is on your trailer coming through your rear window. If you do a head-on at 70 MPH on the Interstate, it won't make much difference if you tied it down with clothesline. The most important trick is to drive with some common sense, and watch out for the idiot that got left out in that department.